You cannot touch to the skin without activating sensory neurons!
With their nerve’s endings innervating all organs including skin and its different cell layers, sensory neurons are sentinels dedicated to inform brain about skin state and to detect all kind of stimuli coming from the environment (temperature, product application….). In addition to this informative role, sensory neurons are also actives cells in the skin able to interact via molecules with skin cells and thus to impact a large variety of biological phenomenon (ageing, wound healing, inflammation…). Based on the culture of human cells, our in-vitro models allow to evaluate compounds effect on this complex sensory neurons / skin cells crosstalk. Thanks to the development of monolayers cultures in 96 well plates or to the use of more complex systems (co-culture system with reconstructed epidermis, Ibidi plates, micro-fluidic chambers) Neuron Experts is able to go from the first intension screening to the test of finish products. As we are able to design specific studies on different supports we not only bring a proof of efficacy of compounds on the skin-sensory neurons interactions but also support claims with proof of concept and mechanism of action identification.