- Adaptation to the external environment (reaction to stimuli)
- Maintenance of the cutaneous homeostasis
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Skin aging
The structure and integrity of the skin varies during the development of the individual. With age, the skin loses its elasticity, wrinkles are deepened, and its protective barrier loses its effectiveness notably leading to significant water loss …
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Inflammatory skin disorders
Urticaria is the most common pathology affecting the skin (20% of the world’s population has been affected or will be affected by an episode of hives) …
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Photo-aging
Physiological aging of the skin is also accelerated by sun exposure. Indeed the skin’s exposure to sunlight (UVA and thermal component) causes an overexpression of metalloproteinases in the skin and collagen deterioration. The activation of TRPV1 receptors (heat component) further enhances this process …
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Skin pigmentation
Skin pigmentation is mainly due to melanin, which is a pigment synthesized by melanocytes and transferred to the cytoplasm of the keratinocytes. Disturbances of its synthesis lead to abnormal pigmentation of the skin (lack of skin pigmentation or skin patches) …
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Soothing
In some people, the skin reacts in an abnormally higher manner to some stimuli (physical, chemical or psychological) causing skin redness, an unpleasant feeling of cutaneous discomfort, or even a sensation of burning and itching. This “pathology” affects 1/3 of the adult population, and even more specifically women …
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Other claims
CGRP is known for its action on the production of insulin-like growth factor (IGF- 1) and its vaso- active role. The stimulation of this neuropeptide is therefore a good indicator for the validation of cosmetic claims below :
Warming sensation
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Microcirculation
Hair growth …
Skin & Sensoriality Skin is the first interface between the human body and its environment. Each variation in this environment like sun exposure, temperature, pressure, but also the application of substances on the skin are all information collected by sensory nerve endings and transmitted to sensory neurons thanks to electrical signals named action potential. 
In reaction, sensory neurons emit an action potential which is transmitted to neurons form the central nervous system allowing perception integration by the brain.
Due to the specific morphology of sensory neurons, an antidromic action potential is also emitted which reaches sensory nerve endings and elicits neurotransmitters to be released. This final action allows for an immediate response of the skin cells. 
Hence a real dialog is established between the skin and sensory neurons. The peripheral nervous system thus plays a dual role:
The deep knowledge of the cutaneous neurosensory environment allows Neuron Experts to provide innovative solutions to the dermo-pharmaceutical and cosmetic industries.
