The pathophysiology of Alzheimer’s disease (AD) is characterized by chronic, progressive neurodegeneration. The precise aetiology of AD is still not fully clarified but is known to be complex and multifactorial. The neurodegeneration seen in AD involves a progressive accumulation of intracellular neurofibrillary tangles, extracellular parenchymal senile plaques, and cerebrovascular deposits; comprised of amyloid-b (Ab) peptides …Read more
Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the United States. The predominant motor symptoms of PD includes slow movement, resting tremor, rigidity, and gait disturbance, which are caused by the loss of dopaminergic neurons in the substantia nigra (SN) …Read more
HD (Huntington’s disease) is an autosomal dominant inherited neurodegenerative disease that affects approximatively / 4–10 cases per 10 000 persons among Caucasians. The mutation causes an unstable huntingtin (htt) protein characterized by an expansion of the polyglutamine tract, leading to the formation of aggregates, decrease in the neurotrophic factor release, mitochondrial and vesicular trafficking impairment …Read more
Stroke, Senile dementia
Stroke and dementia represent a major health issue as they are associated with significant morbidity and mortality. Although the physiopathology of these diseases is complex and multi-factorial, ischemia (oxygen / glucose deprivation) and ischemia-induced excitotoxicity are two common features …Read more
Amyotrophic lateral sclerosis (ALS) disease
ALS is characterized by a progressive loss of both lower motoneurons (spinal cord and brainstem) and upper motoneurons (motor cortex) leading to severe paralysis and death, generally caused by respiratory failure or cardiac arrhythmias. “Amyotrophic” refers to the muscle atrophy, weakness and fasciculation meaning disease of the lower motoneurons …Read more
Neuropathies & demyelinating diseases
A correct production and maintenance of myelin sheath is essential to the proper function of the peripheral nervous system (PNS). Resembling insulation of an electrical wire, the myelin sheath enables electrical signals to be rapidly and correctly conducted along the nerve fiber …Read more
Multiple Sclerosis (MS) is an autoimmune disease leading to demyelination and axonal loss in the brain and spinal cord. The hallmarks of the pathology are plaques found in the myelin-rich white matter region of the central nervous system …Read more
Neurodegenerative diseases are a major health problem. Millions of people worldwide suffer from Alzheimer and other brain-related diseases and there is a major need to find new therapeutic strategies in order to ensure more effective treatments.
In this context, it is essential to have relevant in vitro models of these pathologies. Our studies allow identifying new therapeutic targets and new compounds for therapeutic applications in the following fields.