Other claims
CGRP is known for its action on the production of insulin-like growth factor (IGF- 1) and its vaso- active role. The stimulation of this neuropeptide is therefore a good indicator for the validation of cosmetic claims below:
- Warming sensation
- Microcirculation
- Hair growth
Cell system :
- Primary cultures of mature sensory neurons
- Co- culture of keratinocytes and sensory neurons
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- Sensory Neurons
Endpoint evaluation :
- Measurement of neurotransmitters released by the sensory neurons (CGRP , Substance P , …)
- Measurement of cytokine released by keratinocytes (IGF-1 , VEGF, bFGF … )