Other claims

CGRP is known for its action on the production of insulin-like growth factor (IGF- 1) and its vaso- active role. The stimulation of this neuropeptide is therefore a good indicator for the validation of cosmetic claims below:

  • Warming sensation
  • Microcirculation
  • Hair growth

Cell system :

  • Primary cultures of mature sensory neurons
  • Co- culture of keratinocytes and sensory neurons

Endpoint evaluation :

  • Measurement of neurotransmitters released by the sensory neurons (CGRP , Substance P , …)
  • Measurement of cytokine released by keratinocytes (IGF-1 , VEGF, bFGF … )